AHF: Present and future

Current goals and treatment

  • American College of Cardiology Foundation/American Heart Association (ACCF/AHA) guidelines classify hospitalization for acute HF as: "a sentinel prognostic event in the course of many patients with HF, with a high risk for recurrent hospitalization (eg, 50% at 6 months) and a 1-year mortality rate of approximately 30%"1
  • ACCF/AHA guidelines stress the importance of evaluating myocardial injury in AHF events, using biomarkers such as troponins1
  • No Class I, level of evidence A therapies have been identified for the treatment of acute decompensation of HF1
Current ACCF/AHA recommendations for therapies in the hospitalized HF patient

HFrEF=heart failure with reduced ejection fraction; GDMT=guideline determined medical therapy.

There remain areas of significant unmet need in the treatment of acute heart failure2


  1. Yancy CW, Jessup M, Bozkurt B, et al. 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation. 2013;128(16):e240-e327.
  2. Mann DL, Zipes DP, Libby P, Bonow RO, eds. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. 10th ed. Philadelphia, PA: Saunders; 2015.
  3. NATRECOR [prescribing information]. Mountain View, CA: Scios Inc; 2007.
  4. Simdax, Summary of Product Characteristics. Espoo, Finland: Orion Corporation; 2001.
  5. Simdax, Indications and safety information. http://www.simdax.com/About-Simdax/Indications-and-safetyinformation/. Accessed December 1, 2016.
  6. SAMSCA [prescribing information]. Tokyo, Japan: Otsuka; 2014.
  7. DeVore AD, Hammill BG, Sharma PP, et al. In-hospital worsening heart failure and associations with mortality, readmission, and healthcare utilization. J Am Heart Assoc. 2014;3(4). pii: e001088.
  8. Weatherley BD, Milo-Cotter O, Felker GM, et al. Early worsening heart failure in patients admitted with acute heart failure a new outcome measure associated with long-term prognosis? Fundam Clin Pharmacol. 2009;23(5):633-639.
  9. McMurray JJV, Adamopoulos S, Anker SD, et al. ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: the Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC. Eur Heart J. 2012;33(14):1787-1847.